Reactome | USP19 deubiquitinates RNF123

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:10523880] cysteine-type deubiquitinase activity of USP19:K63polyUb-RNF123 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10523882
displayName	USP19 deubiquitinates RNF123
eventOf	[Pathway:R-SSC-5689880] Ub-specific processing proteases - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6781814] USP19 deubiquitinates RNF123 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-SSC-6783020] USP19:K63polyUb-RNF123 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	USP19 deubiquitinates RNF123
output	[Polymer:R-SSC-450152] K63polyUb [cytosol] [Complex:R-SSC-6783202] USP19:RNF123 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-6781814
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-5689880] Ub-specific processing proteases
(inferredTo)	[Reaction:R-HSA-6781814] USP19 deubiquitinates RNF123

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