Reactome | RHO GTPases activate IQGAPs

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RHO GTPases activate IQGAPs Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10558273
displayName	RHO GTPases activate IQGAPs
eventOf	[Pathway:R-SSC-195258] RHO GTPase Effectors - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SSC-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs - Sus scrofa [Reaction:R-SSC-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin - Sus scrofa [Reaction:R-SSC-5672304] IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 - Sus scrofa [Reaction:R-SSC-5672329] IQGAP1 binds CLIP1 and microtubules - Sus scrofa
inferredFrom	[Pathway:R-HSA-5626467] RHO GTPases activate IQGAPs - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	RHO GTPases activate IQGAPs
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-5626467
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-195258] RHO GTPase Effectors
(hasEncapsulatedEvent)	[Pathway:R-SSC-8848021] Signaling by PTK6
(inferredTo)	[Pathway:R-HSA-5626467] RHO GTPases activate IQGAPs

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