Reactome | Resolution of Sister Chromatid Cohesion

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Resolution of Sister Chromatid Cohesion Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:1598585] chromosome [Compartment:81347] chromosome, centromeric region
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10557845
displayName	Resolution of Sister Chromatid Cohesion
eventOf	[Pathway:R-SSC-68877] Mitotic Prometaphase - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20658] mitotic sister chromatid segregation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-2468293] CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms - Sus scrofa [Reaction:R-SSC-2466068] Phosphorylation of cohesin by PLK1 at chromosomal arms - Sus scrofa [Reaction:R-SSC-2467794] Resolution of sister chromatids - Sus scrofa [Reaction:R-SSC-2545253] Deacetylation of cohesin - Sus scrofa [BlackBoxEvent:R-SSC-2484822] Kinetochore assembly - Sus scrofa [Reaction:R-SSC-2468287] CDK1 phosphorylates CDCA5 (Sororin) at centromeres - Sus scrofa [Reaction:R-SSC-1638803] Phosphorylation of cohesin by PLK1 at centromeres - Sus scrofa [Reaction:R-SSC-1638821] PP2A-B56 dephosphorylates centromeric cohesin - Sus scrofa [Reaction:R-SSC-9851946] FIRRM binds PLK1 - Sus scrofa [Reaction:R-SSC-9851972] PLK1 phosphorylates FIRRM at S43 - Sus scrofa [Reaction:R-SSC-9853372] FIRRM binds PPP1CC - Sus scrofa [Reaction:R-SSC-9853385] PPP1CC dephosphorylates PLK1 - Sus scrofa [Reaction:R-SSC-9853369] PLK1 phosphorylates FIRMM at S744 - Sus scrofa
inferredFrom	[Pathway:R-HSA-2500257] Resolution of Sister Chromatid Cohesion - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Resolution of Sister Chromatid Cohesion
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-2500257
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-68877] Mitotic Prometaphase
(inferredTo)	[Pathway:R-HSA-2500257] Resolution of Sister Chromatid Cohesion