Reactome | Resolution of Sister Chromatid Cohesion

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Resolution of Sister Chromatid Cohesion Show undefined attributes

authored	[InstanceEdit:2500295] Orlic-Milacic, M, 2012-10-02
compartment	[Compartment:70101] cytosol [Compartment:1598585] chromosome [Compartment:81347] chromosome, centromeric region
created	[InstanceEdit:2500256] Orlic-Milacic, M, 2012-10-01
dbId	2500257
displayName	Resolution of Sister Chromatid Cohesion
doi	10.3180/R-HSA-2500257.5
edited	[InstanceEdit:2555380] Matthews, L, 2012-10-05 [InstanceEdit:2555378] Gillespie, ME, 2012-10-05
eventOf	[Pathway:R-HSA-68877] Mitotic Prometaphase - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20658] mitotic sister chromatid segregation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2468293] CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms - Homo sapiens [Reaction:R-HSA-2466068] Phosphorylation of cohesin by PLK1 at chromosomal arms - Homo sapiens [Reaction:R-HSA-2467794] Resolution of sister chromatids - Homo sapiens [Reaction:R-HSA-2545253] Deacetylation of cohesin - Homo sapiens [BlackBoxEvent:R-HSA-2484822] Kinetochore assembly - Homo sapiens [Reaction:R-HSA-2468287] CDK1 phosphorylates CDCA5 (Sororin) at centromeres - Homo sapiens [Reaction:R-HSA-1638803] Phosphorylation of cohesin by PLK1 at centromeres - Homo sapiens [Reaction:R-HSA-1638821] PP2A-B56 dephosphorylates centromeric cohesin - Homo sapiens [Reaction:R-HSA-9851946] FIRRM binds PLK1 - Homo sapiens [Reaction:R-HSA-9851972] PLK1 phosphorylates FIRRM at S43 - Homo sapiens [Reaction:R-HSA-9853372] FIRRM binds PPP1CC - Homo sapiens [Reaction:R-HSA-9853385] PPP1CC dephosphorylates PLK1 - Homo sapiens [Reaction:R-HSA-9853369] PLK1 phosphorylates FIRMM at S744 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2500234] Identification of Xenopus SMC protein complexes required for sister chromatid cohesion [LiteratureReference:163039] Cohesin cleavage by separase required for anaphase and cytokinesis in human cells [LiteratureReference:163990] Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2 [LiteratureReference:2500249] Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization [LiteratureReference:1638818] Shugoshin collaborates with protein phosphatase 2A to protect cohesin [LiteratureReference:2500243] The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis [LiteratureReference:2485011] Sororin mediates sister chromatid cohesion by antagonizing Wapl [LiteratureReference:2468284] Regulation of sororin by Cdk1-mediated phosphorylation [LiteratureReference:2468289] Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion [LiteratureReference:2470256] Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase [LiteratureReference:2470251] Wapl controls the dynamic association of cohesin with chromatin [LiteratureReference:2470265] Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1 [LiteratureReference:2500239] Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	Resolution of Sister Chromatid Cohesion
orthologousEvent	[Pathway:R-SCE-2500257] Resolution of Sister Chromatid Cohesion - Saccharomyces cerevisiae [Pathway:R-MMU-2500257] Resolution of Sister Chromatid Cohesion - Mus musculus [Pathway:R-RNO-2500257] Resolution of Sister Chromatid Cohesion - Rattus norvegicus [Pathway:R-CFA-2500257] Resolution of Sister Chromatid Cohesion - Canis familiaris [Pathway:R-BTA-2500257] Resolution of Sister Chromatid Cohesion - Bos taurus [Pathway:R-SSC-2500257] Resolution of Sister Chromatid Cohesion - Sus scrofa [Pathway:R-DRE-2500257] Resolution of Sister Chromatid Cohesion - Danio rerio [Pathway:R-XTR-2500257] Resolution of Sister Chromatid Cohesion - Xenopus tropicalis [Pathway:R-GGA-2500257] Resolution of Sister Chromatid Cohesion - Gallus gallus [Pathway:R-DME-2500257] Resolution of Sister Chromatid Cohesion - Drosophila melanogaster [Pathway:R-CEL-2500257] Resolution of Sister Chromatid Cohesion - Caenorhabditis elegans [Pathway:R-DDI-2500257] Resolution of Sister Chromatid Cohesion - Dictyostelium discoideum [Pathway:R-SPO-2500257] Resolution of Sister Chromatid Cohesion - Schizosaccharomyces pombe [Pathway:R-PFA-2500257] Resolution of Sister Chromatid Cohesion - Plasmodium falciparum
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-12-04
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2550413] Zhang, Nenggang, 2012-10-22 [InstanceEdit:3110247] Watanabe, Yoshinori, 2012-11-20 [InstanceEdit:3110251] Tanno, Yuji, 2012-11-20 [InstanceEdit:9863560] Liu, Xing, 2024-03-01 [InstanceEdit:9863558] Yao, Xuebiao, 2024-03-01
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2500257
summation	[Summation:2500260] The resolution of sister chromatids in mitotic prometaphase ...

Referrals

(hasEvent)

[Pathway:R-HSA-68877] Mitotic Prometaphase

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