Reactome | CDK1 phosphorylates CDCA5 (Sororin) at centromeres

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CDK1 phosphorylates CDCA5 (Sororin) at centromeres Show undefined attributes

catalystActivity	[CatalystActivity:10504361] cyclin-dependent protein serine/threonine kinase activity of CCNB1,CCNB2:p-T161-CDK1 [cytosol]
category	transition
compartment	[Compartment:81347] chromosome, centromeric region [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10504363
displayName	CDK1 phosphorylates CDCA5 (Sororin) at centromeres
eventOf	[Pathway:R-SSC-2500257] Resolution of Sister Chromatid Cohesion - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-1638803] Phosphorylation of cohesin by PLK1 at centromeres - Sus scrofa
inferredFrom	[Reaction:R-HSA-2468287] CDK1 phosphorylates CDCA5 (Sororin) at centromeres - Homo sapiens
input	[Complex:R-SSC-2484819] Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] 3 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CDK1 phosphorylates CDCA5 (Sororin) at centromeres
output	[Complex:R-SSC-2468282] Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] 3 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[BlackBoxEvent:R-SSC-2484822] Kinetochore assembly - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-2468287
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2500257] Resolution of Sister Chromatid Cohesion
(precedingEvent)	[Reaction:R-SSC-1638803] Phosphorylation of cohesin by PLK1 at centromeres
(inferredTo)	[Reaction:R-HSA-2468287] CDK1 phosphorylates CDCA5 (Sororin) at centromeres

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