Reactome | Phosphorylation of cohesin by PLK1 at centromeres

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Phosphorylation of cohesin by PLK1 at centromeres Show undefined attributes

catalystActivity	[CatalystActivity:10457004] protein serine/threonine kinase activity of p-T210-PLK1 [cytosol]
category	transition
compartment	[Compartment:81347] chromosome, centromeric region [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10494771
displayName	Phosphorylation of cohesin by PLK1 at centromeres
eventOf	[Pathway:R-SSC-2500257] Resolution of Sister Chromatid Cohesion - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-1638821] PP2A-B56 dephosphorylates centromeric cohesin - Sus scrofa
goBiologicalProcess	[GO_BiologicalProcess:18485] sister chromatid cohesion
inferredFrom	[Reaction:R-HSA-1638803] Phosphorylation of cohesin by PLK1 at centromeres - Homo sapiens
input	[Complex:R-SSC-2468282] Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] 2 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of cohesin by PLK1 at centromeres
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SSC-1638796] p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region]
precedingEvent	[Reaction:R-SSC-2468287] CDK1 phosphorylates CDCA5 (Sororin) at centromeres - Sus scrofa [Reaction:R-SSC-3000327] PLK1 phosphorylates BORA - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-1638803
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2500257] Resolution of Sister Chromatid Cohesion
(precedingEvent)	[Reaction:R-SSC-1638821] PP2A-B56 dephosphorylates centromeric cohesin
(inferredTo)	[Reaction:R-HSA-1638803] Phosphorylation of cohesin by PLK1 at centromeres

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