Reactome | PTEN [cytosol]

Schema > EntityWithAccessionedSequence > Entries

PTEN [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:10465694] phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity of PTEN [cytosol] [CatalystActivity:10495338] phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity of PTEN [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-SSC-8847960] PTEN:p-Y387-FRK [cytosol] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-8948775] MKRN1 polyubiquitinates PTEN - Sus scrofa [Reaction:R-SSC-8850945] Casein kinase II phosphorylates PTEN - Sus scrofa [Reaction:R-SSC-8850997] TRIM27 binds PTEN - Sus scrofa [Reaction:R-SSC-6807134] NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN - Sus scrofa [Reaction:R-SSC-6807106] PTEN undergoes monoubiquitination - Sus scrofa [Reaction:R-SSC-8847968] PTEN binds FRK - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10465693
displayName	PTEN [cytosol]
endCoordinate	403
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-199420] PTEN [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-SSC-8850937] PTEN, p-3S,2T-PTEN [cytosol] - Sus scrofa
name	PTEN PTEN F2Z5H1
producedByEvent	[Reaction:R-SSC-8873946] OTUD3 deubiquitinates PTEN - Sus scrofa [Reaction:R-SSC-6807206] USP13 and OTUD3 deubiquitinate PTEN - Sus scrofa [Reaction:R-SSC-6807126] Deubiquitinated PTEN translocates to the cytosol - Sus scrofa
referenceEntity	[ReferenceGeneProduct:uniprot:F2Z5H1] UniProt:F2Z5H1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49633] Sus scrofa
stId	R-SSC-199420
startCoordinate	2

Referrals

(output)	[Reaction:R-SSC-8873946] OTUD3 deubiquitinates PTEN [Reaction:R-SSC-6807206] USP13 and OTUD3 deubiquitinate PTEN [Reaction:R-SSC-6807126] Deubiquitinated PTEN translocates to the cytosol
(hasMember)	[DefinedSet:R-SSC-8850937] PTEN, p-3S,2T-PTEN [cytosol]
(input)	[Reaction:R-SSC-8948775] MKRN1 polyubiquitinates PTEN [Reaction:R-SSC-8847968] PTEN binds FRK [Reaction:R-SSC-8850945] Casein kinase II phosphorylates PTEN [Reaction:R-SSC-8850997] TRIM27 binds PTEN [Reaction:R-SSC-6807134] NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN [Reaction:R-SSC-6807106] PTEN undergoes monoubiquitination
(hasComponent)	[Complex:R-SSC-8847960] PTEN:p-Y387-FRK [cytosol] [Complex:R-SSC-8851000] PTEN:TRIM27 [cytosol] [Complex:R-SSC-199426] PTEN:Mg2+ [cytosol]
(physicalEntity)	[CatalystActivity:10465694] phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity of PTEN [cytosol] [CatalystActivity:10495338] phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity of PTEN [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-199420] PTEN [cytosol]