Reactome | PTPN6 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10488620] protein tyrosine phosphatase activity of PTPN6 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-SSC-205181] PTPN6:p-c-Kit complex [plasma membrane] - Sus scrofa [Complex:R-SSC-913378] Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] - Sus scrofa [Complex:R-SSC-913378] Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] - Sus scrofa [Complex:R-SSC-913378] Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] - Sus scrofa [Complex:R-SSC-913378] Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-205306] Interaction of SHP1 and KIT - Sus scrofa [Reaction:R-SSC-210277] Interaction of PECAM-1 and SHP-1 - Sus scrofa [Reaction:R-SSC-5690701] SHP1 binds p-CD22 - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10468485
displayName	PTPN6 [cytosol]
endCoordinate	595
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-197938] PTPN6 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-SSC-389744] PTPN6,PTPN11 [cytosol] - Sus scrofa
name	PTPN6 A0A4X1UZH9
negativelyRegulates	[NegativeRegulation:10482765] Negative regulation by 'PTPN6 [cytosol]'
referenceEntity	[ReferenceGeneProduct:uniprot:A0A4X1UZH9] UniProt:A0A4X1UZH9
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49633] Sus scrofa
stId	R-SSC-197938
startCoordinate	1

(input)	[Reaction:R-SSC-205306] Interaction of SHP1 and KIT [Reaction:R-SSC-210277] Interaction of PECAM-1 and SHP-1 [Reaction:R-SSC-5690701] SHP1 binds p-CD22
(hasComponent)	[Complex:R-SSC-205181] PTPN6:p-c-Kit complex [plasma membrane] [Complex:R-SSC-210221] PECAM-1:SHP-1 complex [plasma membrane] [Complex:R-SSC-913378] Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] [Complex:R-SSC-5690677] PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane]
(physicalEntity)	[CatalystActivity:10488620] protein tyrosine phosphatase activity of PTPN6 [cytosol]
(regulator)	[NegativeRegulation:10482765] Negative regulation by 'PTPN6 [cytosol]'
(hasMember)	[DefinedSet:R-SSC-389744] PTPN6,PTPN11 [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-197938] PTPN6 [cytosol]