Reactome | Dimeric TGF-beta-1 binds to the receptor

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Dimeric TGF-beta-1 binds to the receptor Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10460032
displayName	Dimeric TGF-beta-1 binds to the receptor
eventOf	[Pathway:R-SSC-2173789] TGF-beta receptor signaling activates SMADs - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-170846] TGFBR2 recruits TGFBR1 - Sus scrofa
inferredFrom	[Reaction:R-HSA-170861] Dimeric TGF-beta-1 binds to the receptor - Homo sapiens
input	[Complex:R-SSC-170852] Dimeric TGFB1 [extracellular region] 2 × [EntityWithAccessionedSequence:R-SSC-170842] TGFBR2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Dimeric TGF-beta-1 binds to the receptor Dimeric TGFB1 binds to TGFBR2 homodimer
output	[Complex:R-SSC-170865] Dimeric TGFB1:TGFBR2 homodimer [plasma membrane]
regulatedBy	[NegativeRegulation:10460033] Negative regulation by 'TGFBR3(1-783):TGFB1,TGFB2 [extracellular region]' [PositiveRegulation:10460008] Positive regulation by 'TGFB1_2:TGFBR3:TGFBR2 [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-170861
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2173789] TGF-beta receptor signaling activates SMADs
(precedingEvent)	[Reaction:R-SSC-170846] TGFBR2 recruits TGFBR1
(inferredTo)	[Reaction:R-HSA-170861] Dimeric TGF-beta-1 binds to the receptor

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