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Schema
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Reaction
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Entries
Dimeric TGF-beta-1 binds to the receptor
Show undefined attributes
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authored
[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02
category
binding
compartment
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:170836] Jassal, B, 2006-01-18 10:19:52
dbId
170861
diseaseReaction
[FailedReaction:R-HSA-3642203] Dimeric TGFB1 does not bind TGFBR2 MSI frameshift mutants - Homo sapiens
displayName
Dimeric TGF-beta-1 binds to the receptor
edited
[InstanceEdit:170836] Jassal, B, 2006-01-18 10:19:52
eventOf
[Pathway:R-HSA-2173789] TGF-beta receptor signaling activates SMADs - Homo sapiens
followingEvent
[Reaction:R-HSA-170846] TGFBR2 recruits TGFBR1 - Homo sapiens
[Reaction:R-HSA-2134519] TGFBR2 is recruited to tight junctions after TGF-beta stimulation - Homo sapiens
input
[Complex:R-HSA-170852] Dimeric TGFB1 [extracellular region]
2 ×
[EntityWithAccessionedSequence:R-HSA-170842] TGFBR2 [plasma membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:177258] The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand
[LiteratureReference:177254] TGF beta signals through a heteromeric protein kinase receptor complex
[LiteratureReference:177261] Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor
[LiteratureReference:3009211] Single-molecule imaging reveals transforming growth factor-beta-induced type II receptor dimerization
maxDepth
1
modified
[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name
Dimeric TGF-beta-1 binds to the receptor
Dimeric TGFB1 binds to TGFBR2 homodimer
orthologousEvent
[Reaction:R-DME-170861] Dimeric TGF-beta-1 binds to the receptor - Drosophila melanogaster
[Reaction:R-XTR-170861] Dimeric TGF-beta-1 binds to the receptor - Xenopus tropicalis
[Reaction:R-DRE-170861] Dimeric TGF-beta-1 binds to the receptor - Danio rerio
[Reaction:R-SSC-170861] Dimeric TGF-beta-1 binds to the receptor - Sus scrofa
[Reaction:R-BTA-170861] Dimeric TGF-beta-1 binds to the receptor - Bos taurus
[Reaction:R-CFA-170861] Dimeric TGF-beta-1 binds to the receptor - Canis familiaris
[Reaction:R-RNO-170861] Dimeric TGF-beta-1 binds to the receptor - Rattus norvegicus
[Reaction:R-MMU-170861] Dimeric TGF-beta-1 binds to the receptor - Mus musculus
output
[Complex:R-HSA-170865] Dimeric TGFB1:TGFBR2 homodimer [plasma membrane]
previousReviewStatus
[ReviewStatus:9821384] two stars
regulatedBy
[NegativeRegulation:9839331] Negative regulation by 'TGFBR3(1-783):TGFB1,TGFB2 [extracellular region]'
[PositiveRegulation:9839330] Positive regulation by 'TGFB1_2:TGFBR3:TGFBR2 [plasma membrane]'
regulationReference
[RegulationReference:9840920] Negative regulation by 'TGFBR3_sol:TGFB1/2' Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites
[RegulationReference:9840922] Positive regulation by 'TGFB1_2:TGFBR3:TGFBR2 [plasma membrane]' Betaglycan presents ligand to the TGF beta signaling receptor
releaseDate
2006-04-24
reviewStatus
[ReviewStatus:9821385] four stars
reviewed
[InstanceEdit:178196] Heldin, CH, 2006-04-18 14:26:12
[InstanceEdit:2250308] Huang, Tao, 2012-05-14
[InstanceEdit:2584311] Chen, Ye-Guang, 2012-11-14
revised
[InstanceEdit:3009245] Orlic-Milacic, M, 2013-02-04
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-170861
summation
[Summation:174852] The mature dimeric TGF-beta-1 (TGFB1) binds with high affini...
updateTrackers
[UpdateTracker:9788659] Update Tracker - [Reaction:170861] Dimeric TGF-beta-1 binds to the receptor - v41:[addLiteratureReference, modifyText]
[UpdateTracker:9787913] Update Tracker - [Reaction:170861] Dimeric TGF-beta-1 binds to the receptor - v44:[addLiteratureReference, add_removeInput, modifyText]
[UpdateTracker:9842358] Update Tracker - [Reaction:170861] Dimeric TGF-beta-1 binds to the receptor - v86:[addRegulator, modifyText]
[UpdateTracker:9789165] Update Tracker - [Reaction:170861] Dimeric TGF-beta-1 binds to the receptor - v38:[modifyText]
[UpdateTracker:9777284] Update Tracker - [Reaction:170861] Dimeric TGF-beta-1 binds to the receptor - v72:[removeCatalystActivity]
Referrals
(updatedInstance)
[UpdateTracker:9788659] Update Tracker - [Reaction:170861] Dimeric TGF-beta-1 binds to the receptor - v41:[addLiteratureReference, modifyText]
[UpdateTracker:9787913] Update Tracker - [Reaction:170861] Dimeric TGF-beta-1 binds to the receptor - v44:[addLiteratureReference, add_removeInput, modifyText]
[UpdateTracker:9842358] Update Tracker - [Reaction:170861] Dimeric TGF-beta-1 binds to the receptor - v86:[addRegulator, modifyText]
[UpdateTracker:9789165] Update Tracker - [Reaction:170861] Dimeric TGF-beta-1 binds to the receptor - v38:[modifyText]
[UpdateTracker:9777284] Update Tracker - [Reaction:170861] Dimeric TGF-beta-1 binds to the receptor - v72:[removeCatalystActivity]
(normalReaction)
[FailedReaction:R-HSA-3642203] Dimeric TGFB1 does not bind TGFBR2 MSI frameshift mutants
(precedingEvent)
[Reaction:R-HSA-2134519] TGFBR2 is recruited to tight junctions after TGF-beta stimulation
[Reaction:R-HSA-170846] TGFBR2 recruits TGFBR1
(hasEvent)
[Pathway:R-HSA-2173789] TGF-beta receptor signaling activates SMADs
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