Reactome | Dimeric TGFB1 [extracellular region]

Schema > Complex > Entries

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-SSC-2395236] TGFB1:LAP1 [extracellular region] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-170861] Dimeric TGF-beta-1 binds to the receptor - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10459938
displayName	Dimeric TGFB1 [extracellular region]
hasComponent	2 × [EntityWithAccessionedSequence:R-SSC-170838] TGFB1 [extracellular region]
inDisease	false
inferredFrom	[Complex:R-HSA-170852] Dimeric TGFB1 [extracellular region] - Homo sapiens
maxDepth	2
name	Dimeric TGFB1
positivelyRegulates	[PositiveRegulation:10537899] Positive regulation by 'Dimeric TGFB1 [extracellular region]'
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-170852
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(hasComponent)	[Complex:R-SSC-2395236] TGFB1:LAP1 [extracellular region] [Complex:R-SSC-170865] Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] [Complex:R-SSC-170840] TGFB1:TGFBR2:TGFBR1 [plasma membrane] [Complex:R-SSC-170841] TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] [Complex:R-SSC-171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] [Complex:R-SSC-171173] TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane] [Complex:R-SSC-171180] TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane]
(regulator)	[PositiveRegulation:10537899] Positive regulation by 'Dimeric TGFB1 [extracellular region]'
(input)	[Reaction:R-SSC-170861] Dimeric TGF-beta-1 binds to the receptor
(inferredTo)	[Complex:R-HSA-170852] Dimeric TGFB1 [extracellular region]