Reactome | TGF-beta receptor signaling activates SMADs

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TGF-beta receptor signaling activates SMADs Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10556523
displayName	TGF-beta receptor signaling activates SMADs
eventOf	[Pathway:R-SSC-170834] Signaling by TGF-beta Receptor Complex - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:19282] transforming growth factor beta receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-170844] Latent TGF-beta-1 is cleaved by FURIN - Sus scrofa [BlackBoxEvent:R-SSC-177107] Secretion and activation of the latent large complex of TGF-beta-1 - Sus scrofa [Reaction:R-SSC-2395328] LTBP1, LTBP3 bind TGF-Beta - Sus scrofa [Reaction:R-SSC-2395364] LTBP4 binds TGF-Beta-1 - Sus scrofa [Reaction:R-SSC-2395320] Latent TGF-beta-1 binds integrins - Sus scrofa [Reaction:R-SSC-2396029] Latent TGF-beta-3 binds integrins - Sus scrofa [Reaction:R-SSC-170861] Dimeric TGF-beta-1 binds to the receptor - Sus scrofa [Reaction:R-SSC-170846] TGFBR2 recruits TGFBR1 - Sus scrofa [Reaction:R-SSC-170843] TGFBR2 phosphorylates TGFBR1 - Sus scrofa [Reaction:R-SSC-170835] An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 - Sus scrofa [Reaction:R-SSC-170868] Activated type I receptor phosphorylates SMAD2/3 directly - Sus scrofa [Reaction:R-SSC-170850] Phosphorylated SMAD2/3 dissociates from TGFBR - Sus scrofa [Reaction:R-SSC-170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - Sus scrofa [Pathway:R-SSC-2173788] Downregulation of TGF-beta receptor signaling - Sus scrofa [Reaction:R-SSC-4332235] CBL binds TGFBR2 - Sus scrofa [Reaction:R-SSC-4332236] CBL neddylates TGFBR2 - Sus scrofa
inferredFrom	[Pathway:R-HSA-2173789] TGF-beta receptor signaling activates SMADs - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	TGF-beta receptor signaling activates SMADs
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-2173789
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-170834] Signaling by TGF-beta Receptor Complex
(inferredTo)	[Pathway:R-HSA-2173789] TGF-beta receptor signaling activates SMADs

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