Reactome | 1-acyl LPA is acylated to PA by AGPAT (LPAAT)

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1-acyl LPA is acylated to PA by AGPAT (LPAAT) Show undefined attributes

catalystActivity	[CatalystActivity:11055003] 1-acylglycerol-3-phosphate O-acyltransferase activity of AGPAT [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11055005
displayName	1-acyl LPA is acylated to PA by AGPAT (LPAAT)
eventOf	[Pathway:R-SPO-1483166] Synthesis of PA - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SPO-75899] 1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate - Schizosaccharomyces pombe [Reaction:R-SPO-1483121] PA is converted to CDP-DAG by CDS1 - Schizosaccharomyces pombe [Reaction:R-SPO-1482656] PA is hydrolysed to 1-acyl LPA by PLA2[1] - Schizosaccharomyces pombe [Reaction:R-SPO-1483203] PA is dephosphorylated to DAG by LPIN - Schizosaccharomyces pombe
inferredFrom	[Reaction:R-HSA-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Homo sapiens
input	[SimpleEntity:R-ALL-1500604] 1-acyl LPA [cytosol] [SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	1-acyl LPA is acylated to PA by AGPAT (LPAAT) 1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH lysophosphatidic acid + fatty acyl CoA => phosphatidic acid + CoA (1)
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-426755] PA [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-SPO-1482656] PA is hydrolysed to 1-acyl LPA by PLA2[1] - Schizosaccharomyces pombe
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-75885
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-1483166] Synthesis of PA
(precedingEvent)	[Reaction:R-SPO-75899] 1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate [Reaction:R-SPO-1483121] PA is converted to CDP-DAG by CDS1 [Reaction:R-SPO-1483203] PA is dephosphorylated to DAG by LPIN [Reaction:R-SPO-1482656] PA is hydrolysed to 1-acyl LPA by PLA2[1]
(inferredTo)	[Reaction:R-HSA-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT)

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