Reactome | PA is hydrolysed to 1-acyl LPA by PLA2[1]

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PA is hydrolysed to 1-acyl LPA by PLA2[1] Show undefined attributes

catalystActivity	[CatalystActivity:11062591] A2-type glycerophospholipase activity of PLA2(1) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11062643
displayName	PA is hydrolysed to 1-acyl LPA by PLA2[1]
eventOf	[Pathway:R-SPO-1483166] Synthesis of PA - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SPO-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Schizosaccharomyces pombe
inferredFrom	[Reaction:R-HSA-1482656] PA is hydrolysed to 1-acyl LPA by PLA2[1] - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-426755] PA [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PA is hydrolysed to 1-acyl LPA by PLA2[1]
output	[SimpleEntity:R-ALL-1500604] 1-acyl LPA [cytosol] [SimpleEntity:R-ALL-1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-SPO-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Schizosaccharomyces pombe [Reaction:R-SPO-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Schizosaccharomyces pombe
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-1482656
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-1483166] Synthesis of PA
(precedingEvent)	[Reaction:R-SPO-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT)
(inferredTo)	[Reaction:R-HSA-1482656] PA is hydrolysed to 1-acyl LPA by PLA2[1]

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