Reactome | Synthesis of PA

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Synthesis of PA Show undefined attributes

created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11078513
displayName	Synthesis of PA
eventOf	[Pathway:R-SPO-1483206] Glycerophospholipid biosynthesis - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20462] phosphatidic acid biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SPO-188467] Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) - Schizosaccharomyces pombe [Reaction:R-SPO-75889] DHAP is converted to G3P by GPD1/GPD1L - Schizosaccharomyces pombe [Reaction:R-SPO-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Schizosaccharomyces pombe [Reaction:R-SPO-1482656] PA is hydrolysed to 1-acyl LPA by PLA2[1] - Schizosaccharomyces pombe [Reaction:R-SPO-1482548] 1-acyl LPA is acylated to PA by AGPAT5 (OM) - Schizosaccharomyces pombe [Reaction:R-SPO-1482604] PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) - Schizosaccharomyces pombe [Reaction:R-SPO-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Schizosaccharomyces pombe [Reaction:R-SPO-6786650] DDHD1,2 hydrolyse PA - Schizosaccharomyces pombe [Reaction:R-SPO-8878654] ACP6 hydrolyses MYS-LPA - Schizosaccharomyces pombe [Reaction:R-SPO-8878787] ALPI dimer hydrolyses phosphate monoesters - Schizosaccharomyces pombe
inferredFrom	[Pathway:R-HSA-1483166] Synthesis of PA - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Synthesis of PA
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-1483166
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-1483206] Glycerophospholipid biosynthesis
(inferredTo)	[Pathway:R-HSA-1483166] Synthesis of PA

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