Reactome | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide

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Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10225547
displayName	Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
eventOf	[Pathway:R-RNO-9948299] Ribosome-associated quality control - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-9948360] NEMF binds 60S ribosomal subunit:peptidyl-tRNA with nascent peptide - Rattus norvegicus [BlackBoxEvent:R-RNO-9954723] NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide - Rattus norvegicus [Reaction:R-RNO-9954721] NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide - Rattus norvegicus [BlackBoxEvent:R-RNO-9954727] RCHY1 binds alanine-tailed nascent peptide and Ub:UBE2D2 - Rattus norvegicus [Reaction:R-RNO-9954737] RCHY1 K48 polyubiquitinates alanine-tailed nascent peptide - Rattus norvegicus [BlackBoxEvent:R-RNO-9954728] The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide - Rattus norvegicus [Reaction:R-RNO-9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala - Rattus norvegicus [Reaction:R-RNO-9948362] LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-9954709] Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9954709
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9948299] Ribosome-associated quality control
(inferredTo)	[Pathway:R-HSA-9954709] Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide

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