Reactome | Ribosome-associated quality control

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Ribosome-associated quality control Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10225545
displayName	Ribosome-associated quality control
eventOf	[Pathway:R-RNO-72766] Translation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1042910] rescue of stalled cytosolic ribosome
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-RNO-9954716] ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA - Rattus norvegicus [Pathway:R-RNO-9954714] PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA - Rattus norvegicus [Pathway:R-RNO-9954709] Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-9948299] Ribosome-associated quality control - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Ribosome-associated quality control
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9948299
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-72766] Translation
(inferredTo)	[Pathway:R-HSA-9948299] Ribosome-associated quality control

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