Reactome | LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide

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LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide Show undefined attributes

catalystActivity	[CatalystActivity:10221444] ubiquitin protein ligase activity of LTN1:TCF25:NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10221446
displayName	LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide
eventOf	[Pathway:R-RNO-9954709] Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9948362] LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide - Homo sapiens
input	[Complex:R-RNO-9948455] LTN1:TCF25:NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala [cytosol] 3 × [Complex:R-RNO-8939319] Ub:UBE2D1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide
output	[Complex:R-RNO-9948361] LTN1:TCF25:NEMF:60S ribosomal subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol] 3 × [EntityWithAccessionedSequence:R-RNO-174236] Ube2d1 [cytosol]
precedingEvent	[Reaction:R-RNO-9948318] LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9948362
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9954709] Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
(inferredTo)	[Reaction:R-HSA-9948362] LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide

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