Reactome | The complex of MDM2 and CDH1 translocates to early endosomes

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The complex of MDM2 and CDH1 translocates to early endosomes Show undefined attributes

category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:171062] early endosome membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10220571
displayName	The complex of MDM2 and CDH1 translocates to early endosomes
eventOf	[Pathway:R-RNO-9766229] Degradation of CDH1 - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-9766223] Proteasome-dependent degradation of ubiquitinated CDH1 - Rattus norvegicus
inferredFrom	[BlackBoxEvent:R-HSA-9934584] The complex of MDM2 and CDH1 translocates to early endosomes - Homo sapiens
input	[Complex:R-RNO-9934664] PolyUbK48-CDH1:MDM2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	The complex of MDM2 and CDH1 translocates to early endosomes
output	[Complex:R-RNO-9934666] PolyUbK48-CDH1:MDM2 [early endosome membrane]
precedingEvent	[BlackBoxEvent:R-RNO-9766227] MDM2 mediates CDH1 ubiquitination - Rattus norvegicus
regulatedBy	[PositiveRegulation:10220572] Positive regulation by 'EPS15 [cytosol]' [PositiveRegulation:10220573] Positive regulation by 'DNM2 [plasma membrane]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9934584
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9766229] Degradation of CDH1
(precedingEvent)	[BlackBoxEvent:R-RNO-9766223] Proteasome-dependent degradation of ubiquitinated CDH1
(inferredTo)	[BlackBoxEvent:R-HSA-9934584] The complex of MDM2 and CDH1 translocates to early endosomes

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