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Itch [cytosol]
Stable Identifier
R-RNO-975995
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
ITCH, A0A8I5ZZU1
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional regulation by RUNX1 (Rattus norvegicus)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Rattus norvegicus)
ITCH polyubiquitinates TP73 (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
Polyubiquitination of substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Rattus norvegicus)
NOD1/2 Signaling Pathway (Rattus norvegicus)
RIP2 is K63 polyubiquitinated (Rattus norvegicus)
RIP2 ubiquitin ligases [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
Programmed Cell Death (Rattus norvegicus)
Regulated Necrosis (Rattus norvegicus)
RIPK1-mediated regulated necrosis (Rattus norvegicus)
Regulation of necroptotic cell death (Rattus norvegicus)
ITCH polyubiquitinates MLKL at K50 (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
MLKL binds ITCH (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Hedgehog (Rattus norvegicus)
Hedgehog 'off' state (Rattus norvegicus)
Degradation of GLI1 by the proteasome (Rattus norvegicus)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Rattus norvegicus)
NUMB:ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Rattus norvegicus)
NUMB:ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
NUMB binds ITCH (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
NUMB:ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
NUMB:ITCH bind and ubiquitnate GLI1 (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
NUMB:ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Rattus norvegicus)
NUMB:ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
Hedgehog 'on' state (Rattus norvegicus)
NUMB binds ITCH (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
NUMB:ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
NUMB:ITCH binds GLI1 (Rattus norvegicus)
GLI1:NUMB:ITCH [cytosol] (Rattus norvegicus)
NUMB:ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
NUMB:ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
NUMB:ITCH ubiquitinates GLI1 (Rattus norvegicus)
GLI1:NUMB:ITCH [cytosol] (Rattus norvegicus)
NUMB:ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
ub-GLI1:NUMB:ITCH [cytosol] (Rattus norvegicus)
NUMB:ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
ub-GLI is degraded by the proteasome (Rattus norvegicus)
NUMB:ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
ub-GLI1:NUMB:ITCH [cytosol] (Rattus norvegicus)
NUMB:ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
Signaling by NOTCH (Rattus norvegicus)
Signaling by NOTCH1 (Rattus norvegicus)
Activated NOTCH1 Transmits Signal to the Nucleus (Rattus norvegicus)
ITCH binds DTX (Rattus norvegicus)
DTX:ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
ITCH ubiquitinates DTX (Rattus norvegicus)
DTX:ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
Ub-DTX:ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ERBB4 (Rattus norvegicus)
Downregulation of ERBB4 signaling (Rattus norvegicus)
ERBB4 binds WWP1/ITCH ubiquitin ligases (Rattus norvegicus)
ERBB4/m80/s80:WWP1/ITCH [plasma membrane] (Rattus norvegicus)
WWP1/ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
WWP1/ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
ERBB4 ubiquitination by WWP1/ITCH (Rattus norvegicus)
ERBB4/m80/s80:WWP1/ITCH [plasma membrane] (Rattus norvegicus)
WWP1/ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
Ub-ERBB4:WWP1/ITCH [plasma membrane] (Rattus norvegicus)
WWP1/ITCH [cytosol] (Rattus norvegicus)
Itch [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:A0A8I5ZZU1
Gene Names
Itch
Reference Genes
ENSEMBL:ENSRNOG00000059043
ENSEMBL:ENSRNOG00000059043.2 Itch
Other Identifiers
10841301
1383636_at
1393310_at
17767910
311567
5652369
5655976
5677539
5680634
5696021
5750283
5807464
5954386
6002088
6017521
6065725
6067104
6130416
6154908
6194616
6203585
6233501
6402347
6415495
6515764
6579834
6646231
6663284
6697513
6701809
6709168
6733386
GE1222915
GE14390
GO:0000209
GO:0002376
GO:0002669
GO:0002870
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005769
GO:0005886
GO:0005938
GO:0006511
GO:0006513
GO:0007155
GO:0012501
GO:0016020
GO:0016192
GO:0016567
GO:0016740
GO:0016874
GO:0023052
GO:0030163
GO:0031410
GO:0031623
GO:0032991
GO:0035519
GO:0035739
GO:0036211
GO:0043021
GO:0043066
GO:0043161
GO:0043226
GO:0043231
GO:0044389
GO:0045236
GO:0045732
GO:0046329
GO:0048856
GO:0050687
GO:0051865
GO:0061630
GO:0070534
GO:0070936
GO:0090085
GO:0098542
GO:0140096
GO:1990763
GO:2000562
GO:2000646
ILMN_1373173
rc_AA998387_at
rc_AI175457_at
Participates
as a member of
WWP1/ITCH [cytosol] (Rattus norvegicus)
RIP2 ubiquitin ligases [cytosol] (Rattus norvegicus)
as an input of
NUMB binds ITCH (Rattus norvegicus)
ITCH binds DTX (Rattus norvegicus)
MLKL binds ITCH (Rattus norvegicus)
as a component of
NUMB:ITCH [cytosol] (Rattus norvegicus)
Ub-DTX:ITCH [cytosol] (Rattus norvegicus)
DTX:ITCH [cytosol] (Rattus norvegicus)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Rattus norvegicus)
as an output of
ITCH polyubiquitinates MLKL at K50 (Rattus norvegicus)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
Other forms of this molecule
Itch [cytosol]
Inferred From
ITCH [cytosol]
(Homo sapiens)
Cross References
Ensembl
ENSRNOT00000105016
,
ENSRNOP00000083747
,
ENSRNOG00000059043
RGD
1359556
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