Reactome | ABCB1 transports PREDN,PREDL out of hepatic cells

Schema > Reaction > Entries

ABCB1 transports PREDN,PREDL out of hepatic cells Show undefined attributes

catalystActivity	[CatalystActivity:10212442] ATPase-coupled transmembrane transporter activity of ABCB1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10215216
displayName	ABCB1 transports PREDN,PREDL out of hepatic cells
eventOf	[Pathway:R-RNO-9757110] Prednisone ADME - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9759461] ABCB1 transports PREDN,PREDL out of hepatic cells - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [DefinedSet:R-ALL-9759400] PREDN,PREDL (hepatocyte) [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ABCB1 transports PREDN,PREDL out of hepatic cells
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [DefinedSet:R-ALL-9757122] PREDN,PREDL [extracellular region]
precedingEvent	[Reaction:R-RNO-9757706] HSD11B1 hydrogenates PREDN to PREDL in hepatic cell - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9759461
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9757110] Prednisone ADME
(inferredTo)	[Reaction:R-HSA-9759461] ABCB1 transports PREDN,PREDL out of hepatic cells

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