Reactome | HSD11B1 hydrogenates PREDN to PREDL in hepatic cell

Schema > Reaction > Entries

HSD11B1 hydrogenates PREDN to PREDL in hepatic cell Show undefined attributes

catalystActivity	[CatalystActivity:10215127] 11-beta-hydroxysteroid dehydrogenase (NADP+) activity of HSD11B1 dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10215129
displayName	HSD11B1 hydrogenates PREDN to PREDL in hepatic cell
eventOf	[Pathway:R-RNO-9757110] Prednisone ADME - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9759461] ABCB1 transports PREDN,PREDL out of hepatic cells - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9757706] HSD11B1 hydrogenates PREDN to PREDL in hepatic cell - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [ChemicalDrug:R-ALL-9759404] PREDN (hepatocyte) [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HSD11B1 hydrogenates PREDN to PREDL in hepatic cell
output	[SimpleEntity:R-ALL-29366] NADP+ [cytosol] [ChemicalDrug:R-ALL-9759402] PREDL (hepatocyte) [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9757706
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9757110] Prednisone ADME
(precedingEvent)	[Reaction:R-RNO-9759461] ABCB1 transports PREDN,PREDL out of hepatic cells
(inferredTo)	[Reaction:R-HSA-9757706] HSD11B1 hydrogenates PREDN to PREDL in hepatic cell

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