Reactome | TNF-alpha inhibitors bind to TNF(1-233) trimer

Schema > Reaction > Entries

TNF-alpha inhibitors bind to TNF(1-233) trimer Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10214433
displayName	TNF-alpha inhibitors bind to TNF(1-233) trimer
eventOf	[Pathway:R-RNO-75893] TNF signaling - Rattus norvegicus [Pathway:R-RNO-5668541] TNFR2 non-canonical NF-kB pathway - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer - Homo sapiens
input	[Complex:R-RNO-3371351] TNF(1-233) trimer [plasma membrane] [DefinedSet:R-ALL-9714904] TNF-alpha inhibitors [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	TNF-alpha inhibitors bind to TNF(1-233) trimer
output	[Complex:R-RNO-9714982] TNF-alpha inhibitors:TNF(1-233) trimer [plasma membrane]
precedingEvent	[Reaction:R-RNO-3371385] TNF-? is cleaved by ADAM17 (TACE) - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9714959
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5668541] TNFR2 non-canonical NF-kB pathway [Pathway:R-RNO-75893] TNF signaling
(inferredTo)	[Reaction:R-HSA-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer

Cite Us!