Reactome | TNF-alpha inhibitors [extracellular region]

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TNF-alpha inhibitors [extracellular region] Show undefined attributes

authored	[InstanceEdit:9714531] Stephan, Ralf, 2021-02-12
compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-HSA-9714982] TNF-alpha inhibitors:TNF(1-233) trimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9714968] TNF-alpha inhibitors:TNF-alpha trimer, soluble form [extracellular region] - Homo sapiens
consumedByEvent	[Reaction:R-XTR-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer - Xenopus tropicalis [Reaction:R-DRE-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer - Danio rerio [Reaction:R-SSC-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer - Sus scrofa [Reaction:R-BTA-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer - Bos taurus [Reaction:R-CFA-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer - Canis familiaris [Reaction:R-RNO-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer - Rattus norvegicus [Reaction:R-HSA-9714924] TNF-alpha inhibitors bind to soluble TNF trimer - Homo sapiens [Reaction:R-MMU-9714924] TNF-alpha inhibitors bind to soluble TNF trimer - Mus musculus [Reaction:R-RNO-9714924] TNF-alpha inhibitors bind to soluble TNF trimer - Rattus norvegicus [Reaction:R-CFA-9714924] TNF-alpha inhibitors bind to soluble TNF trimer - Canis familiaris [Reaction:R-BTA-9714924] TNF-alpha inhibitors bind to soluble TNF trimer - Bos taurus [Reaction:R-SSC-9714924] TNF-alpha inhibitors bind to soluble TNF trimer - Sus scrofa [Reaction:R-DRE-9714924] TNF-alpha inhibitors bind to soluble TNF trimer - Danio rerio [Reaction:R-XTR-9714924] TNF-alpha inhibitors bind to soluble TNF trimer - Xenopus tropicalis [Reaction:R-HSA-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer - Homo sapiens [Reaction:R-MMU-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer - Mus musculus
created	[InstanceEdit:9715007] Stephan, Ralf, 2021-02-16
crossReference	[DatabaseIdentifier:12021177] Mondo:0007191
dbId	9714904
disease	[Disease:9659865] Behcet's disease [Disease:9660768] Crohn's disease [Disease:9660849] ankylosing spondylitis [Disease:9714534] hidradenitis suppurativa [Disease:9660847] juvenile rheumatoid arthritis [Disease:9009814] psoriasis [Disease:9660843] psoriatic arthritis [Disease:5663017] rheumatoid arthritis [Disease:9625953] ulcerative colitis [Disease:9714290] uveitis [Disease:9677533] inflammation
displayName	TNF-alpha inhibitors [extracellular region]
hasMember	[ProteinDrug:R-ALL-9714991] adalimumab [extracellular region] [ProteinDrug:R-ALL-9714963] certolizumab pegol [extracellular region] [ProteinDrug:R-ALL-9714949] etanercept [extracellular region] [ProteinDrug:R-ALL-9714993] golimumab [extracellular region] [ProteinDrug:R-ALL-9714952] infliximab [extracellular region]
inDisease	true
literatureReference	[LiteratureReference:9714927] Anti-TNF alpha therapy is useful in rheumatoid arthritis and Crohn's disease: analysis of the mechanism of action predicts utility in other diseases [LiteratureReference:9714926] TNF-alpha inhibitors for ankylosing spondylitis [LiteratureReference:9714925] A comprehensive review and evaluation of the side effects of the tumor necrosis factor alpha blockers etanercept, infliximab and adalimumab [LiteratureReference:9714910] Treatment of hidradenitis suppurativa with tumour necrosis factor-alpha inhibitors [LiteratureReference:9714929] Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis
maxDepth	2
name	TNF-alpha inhibitors
schemaClass	DefinedSet
stId	R-ALL-9714904

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