Reactome | TNF(1-233) trimer [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-RNO-74277] TNF-?:TNFR1 [plasma membrane] - Rattus norvegicus [Complex:R-RNO-5668502] TNFA trimer:TNFR2 [plasma membrane] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-83660] Membrane-anchored TNF-? binds TNFR1 - Rattus norvegicus [Reaction:R-RNO-3371385] TNF-? is cleaved by ADAM17 (TACE) - Rattus norvegicus [Reaction:R-RNO-5668404] TNFA binds TNFR2 - Rattus norvegicus [Reaction:R-RNO-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10110615
displayName	TNF(1-233) trimer [plasma membrane]
hasComponent	3 × [EntityWithAccessionedSequence:R-RNO-66220] Tnf [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-3371351] TNF(1-233) trimer [plasma membrane] - Homo sapiens
maxDepth	2
name	TNF(1-233) trimer
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-3371351
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-RNO-5668404] TNFA binds TNFR2 [Reaction:R-RNO-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer [Reaction:R-RNO-83660] Membrane-anchored TNF-? binds TNFR1 [Reaction:R-RNO-3371385] TNF-? is cleaved by ADAM17 (TACE)
(hasComponent)	[Complex:R-RNO-5668502] TNFA trimer:TNFR2 [plasma membrane] [Complex:R-RNO-5668423] TNFA trimer:TNFR2 trimer [plasma membrane] [Complex:R-RNO-9714982] TNF-alpha inhibitors:TNF(1-233) trimer [plasma membrane] [Complex:R-RNO-74277] TNF-?:TNFR1 [plasma membrane]
(inferredTo)	[Complex:R-HSA-3371351] TNF(1-233) trimer [plasma membrane]