Reactome | SRD5A3 dehydrogenates TEST to DHTEST

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SRD5A3 dehydrogenates TEST to DHTEST Show undefined attributes

authored	[InstanceEdit:469658] Jassal, B, 2010-01-25
catalystActivity	[CatalystActivity:9705710] 3-oxo-5-alpha-steroid 4-dehydrogenase activity of SRD5A3 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9705709] Jassal, Bijay, 2020-10-29
crossReference	[DatabaseIdentifier:12668254] RHEA:50822
dbId	9705714
displayName	SRD5A3 dehydrogenates TEST to DHTEST
edited	[InstanceEdit:469658] Jassal, B, 2010-01-25
eventOf	[Pathway:R-HSA-193048] Androgen biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-9705925] Androgens binds AR (in the HSP90 chaperone complex) - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-193057] TEST [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:469666] Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer [LiteratureReference:1434477] A critical review of the origin and control of adrenal androgens
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SRD5A3 dehydrogenates TEST to DHTEST Testosterone is converted to 5-alpha-dihydroxytestosterone
orthologousEvent	[Reaction:R-PFA-9705714] SRD5A3 dehydrogenates TEST to DHTEST - Plasmodium falciparum [Reaction:R-SCE-9705714] SRD5A3 dehydrogenates TEST to DHTEST - Saccharomyces cerevisiae [Reaction:R-SPO-9705714] SRD5A3 dehydrogenates TEST to DHTEST - Schizosaccharomyces pombe [Reaction:R-DDI-9705714] SRD5A3 dehydrogenates TEST to DHTEST - Dictyostelium discoideum [Reaction:R-CEL-9705714] SRD5A3 dehydrogenates TEST to DHTEST - Caenorhabditis elegans [Reaction:R-DME-9705714] SRD5A3 dehydrogenates TEST to DHTEST - Drosophila melanogaster [Reaction:R-GGA-9705714] SRD5A3 dehydrogenates TEST to DHTEST - Gallus gallus [Reaction:R-XTR-9705714] SRD5A3 dehydrogenates TEST to DHTEST - Xenopus tropicalis [Reaction:R-DRE-9705714] SRD5A3 dehydrogenates TEST to DHTEST - Danio rerio [Reaction:R-SSC-9705714] SRD5A3 dehydrogenates TEST to DHTEST - Sus scrofa [Reaction:R-BTA-9705714] SRD5A3 dehydrogenates TEST to DHTEST - Bos taurus [Reaction:R-CFA-9705714] SRD5A3 dehydrogenates TEST to DHTEST - Canis familiaris [Reaction:R-RNO-9705714] SRD5A3 dehydrogenates TEST to DHTEST - Rattus norvegicus [Reaction:R-MMU-9705714] SRD5A3 dehydrogenates TEST to DHTEST - Mus musculus
output	[SimpleEntity:R-ALL-469662] DHTEST [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-193064] HSD17B3-like proteins reducde ANDST to TEST - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-1449720] Positive regulation by 'POMC(138-176) [cytosol]'
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9705714
summation	[Summation:9705708] The conversion of testosterone (TEST) to the most potent and...

Referrals

(hasEvent)	[Pathway:R-HSA-193048] Androgen biosynthesis
(precedingEvent)	[Reaction:R-HSA-9705925] Androgens binds AR (in the HSP90 chaperone complex)