Reactome | MCOLN1 transports Fe2+ from endosome lumen to cytosol

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MCOLN1 transports Fe2+ from endosome lumen to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10145808] iron ion transmembrane transporter activity of MCOLN1 [endosome membrane]
category	transition
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10145810
displayName	MCOLN1 transports Fe2+ from endosome lumen to cytosol
eventOf	[Pathway:R-RNO-917977] Transferrin endocytosis and recycling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-917936] MCOLN1 transports Fe2+ from endosome lumen to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-917810] Fe2+ [endosome lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	MCOLN1 transports Fe2+ from endosome lumen to cytosol Iron diffuses out of the endosome
output	[SimpleEntity:R-ALL-71067] Fe2+ [cytosol]
precedingEvent	[Reaction:R-RNO-917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-917936
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-917977] Transferrin endocytosis and recycling
(inferredTo)	[Reaction:R-HSA-917936] MCOLN1 transports Fe2+ from endosome lumen to cytosol

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