Reactome | Acidification of Tf:TfR1 containing endosome

Schema > Reaction > Entries

Acidification of Tf:TfR1 containing endosome Show undefined attributes

catalystActivity	[CatalystActivity:10108539] proton transmembrane transporter activity of V-ATPase:ATP6AP1 [endosome membrane]
category	transition
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10145792
displayName	Acidification of Tf:TfR1 containing endosome
eventOf	[Pathway:R-RNO-917977] Transferrin endocytosis and recycling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-917835] Fe3+ dissociates from holoTF:TFRC dimer - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-917841] Acidification of Tf:TfR1 containing endosome - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] 3 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Acidification of Tf:TfR1 containing endosome
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] 3 × [SimpleEntity:R-ALL-74722] H+ [endosome lumen] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[BlackBoxEvent:R-RNO-917807] holoTF:TFRC dimer translocates from plasma membrane to endosome membrane - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-917841
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-917977] Transferrin endocytosis and recycling
(precedingEvent)	[Reaction:R-RNO-917835] Fe3+ dissociates from holoTF:TFRC dimer
(inferredTo)	[Reaction:R-HSA-917841] Acidification of Tf:TfR1 containing endosome

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