Reactome | Degradation of GABA

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Degradation of GABA Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224005
displayName	Degradation of GABA
eventOf	[Pathway:R-RNO-888590] GABA synthesis, release, reuptake and degradation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:26324] gamma-aminobutyric acid catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - Rattus norvegicus [Reaction:R-RNO-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-916853] Degradation of GABA - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Degradation of GABA
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-916853
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-888590] GABA synthesis, release, reuptake and degradation
(inferredTo)	[Pathway:R-HSA-916853] Degradation of GABA