Reactome | Ub-misfolded nascent CFTR [cytosol]

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Ub-misfolded nascent CFTR [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-8866535] Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] - Homo sapiens
consumedByEvent	[BlackBoxEvent:R-HSA-8866553] misfolded CFTR is degraded by the 26S proteasome - Homo sapiens
created	[InstanceEdit:8866532] Rothfels, Karen, 2016-04-01
dbId	8866534
displayName	Ub-misfolded nascent CFTR [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-HSA-8868730] misfolded CFTR [endoplasmic reticulum membrane] [DefinedSet:R-HSA-113595] Ub [cytosol]
inDisease	false
includedLocation	[Compartment:12045] endoplasmic reticulum membrane
inferredTo	[Complex:R-MMU-8866534] Ub-misfolded nascent CFTR [cytosol] - Mus musculus [Complex:R-RNO-8866534] Ub-misfolded nascent CFTR [cytosol] - Rattus norvegicus [Complex:R-CFA-8866534] Ub-misfolded nascent CFTR [cytosol] - Canis familiaris [Complex:R-BTA-8866534] Ub-misfolded nascent CFTR [cytosol] - Bos taurus [Complex:R-SSC-8866534] Ub-misfolded nascent CFTR [cytosol] - Sus scrofa [Complex:R-DRE-8866534] Ub-misfolded nascent CFTR [cytosol] - Danio rerio [Complex:R-XTR-8866534] Ub-misfolded nascent CFTR [cytosol] - Xenopus tropicalis [Complex:R-GGA-8866534] Ub-misfolded nascent CFTR [cytosol] - Gallus gallus [Complex:R-DME-8866534] Ub-misfolded nascent CFTR [cytosol] - Drosophila melanogaster [Complex:R-CEL-8866534] Ub-misfolded nascent CFTR [cytosol] - Caenorhabditis elegans [Complex:R-DDI-8866534] Ub-misfolded nascent CFTR [cytosol] - Dictyostelium discoideum [Complex:R-PFA-8866534] Ub-misfolded nascent CFTR [cytosol] - Plasmodium falciparum
isChimeric	false
maxDepth	3
memberOf	[DefinedSet:R-HSA-9641117] Ub-Misfolded Proteins [cytosol] - Homo sapiens
modified	[InstanceEdit:9634791] Rothfels, Karen, 2019-01-15
name	Ub-misfolded nascent CFTR
producedByEvent	[Reaction:R-HSA-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-8866534
updateTrackers	[UpdateTracker:9897297] Update Tracker - [Complex:8866534] Ub-misfolded nascent CFTR [cytosol] - v61:[updateContainedComponent] [UpdateTracker:9900241] Update Tracker - [Complex:8866534] Ub-misfolded nascent CFTR [cytosol] - v68:[add_removeHasComponent]

Referrals

(updatedInstance)	[UpdateTracker:9897297] Update Tracker - [Complex:8866534] Ub-misfolded nascent CFTR [cytosol] - v61:[updateContainedComponent] [UpdateTracker:9900241] Update Tracker - [Complex:8866534] Ub-misfolded nascent CFTR [cytosol] - v68:[add_removeHasComponent]
(normalEntity)	[EntityFunctionalStatus:9630131] gain_of_function of ub-CFTR F508del [cytosol]
(input)	[BlackBoxEvent:R-HSA-8866553] misfolded CFTR is degraded by the 26S proteasome
(output)	[Reaction:R-HSA-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
(hasComponent)	[Complex:R-HSA-8866535] Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane]
(hasMember)	[DefinedSet:R-HSA-9641117] Ub-Misfolded Proteins [cytosol]

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