Reactome | Caspase activation via extrinsic apoptotic signalling pathway

Schema > Pathway > Entries

Caspase activation via extrinsic apoptotic signalling pathway Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222193
displayName	Caspase activation via extrinsic apoptotic signalling pathway
eventOf	[Pathway:R-RNO-109581] Apoptosis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2133498] extrinsic apoptotic signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-RNO-140534] Caspase activation via Death Receptors in the presence of ligand - Rattus norvegicus [Pathway:R-RNO-418889] Caspase activation via Dependence Receptors in the absence of ligand - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-5357769] Caspase activation via extrinsic apoptotic signalling pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	Caspase activation via extrinsic apoptotic signalling pathway
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5357769
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-109581] Apoptosis
(inferredTo)	[Pathway:R-HSA-5357769] Caspase activation via extrinsic apoptotic signalling pathway

© 2026 Reactome

Cite Us!