Reactome | Purine catabolism

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Purine catabolism Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222215
displayName	Purine catabolism
eventOf	[Pathway:R-RNO-8956319] Nucleotide catabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:16129] purine nucleotide catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-109278] NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP - Rattus norvegicus [Reaction:R-RNO-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Rattus norvegicus [Reaction:R-RNO-109415] AMP + H2O => adenosine + orthophosphate [NT5C1B] - Rattus norvegicus [Reaction:R-RNO-109387] (2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A] - Rattus norvegicus [Reaction:R-RNO-109470] (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) - Rattus norvegicus [Reaction:R-RNO-8953339] DNPH1 hydrolyses dGMP - Rattus norvegicus [Reaction:R-RNO-74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose - Rattus norvegicus [Reaction:R-RNO-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - Rattus norvegicus [Reaction:R-RNO-74255] Guanine + H2O => Xanthine + NH4+ - Rattus norvegicus [Reaction:R-RNO-74247] XDH oxidizes hypoxanthine to form xanthine - Rattus norvegicus [Reaction:R-RNO-9727347] XDH dehydrogenates hypoxanthine to form xanthine - Rattus norvegicus [Reaction:R-RNO-74258] XDH oxidizes xanthine to form urate - Rattus norvegicus [Reaction:R-RNO-9727349] XDH dehydrogenates xanthine to form urate - Rattus norvegicus [Pathway:R-RNO-2393930] Phosphate bond hydrolysis by NUDT proteins - Rattus norvegicus [Reaction:R-RNO-2509827] ITPA hydrolyses ITP to IMP - Rattus norvegicus [Reaction:R-RNO-2509831] ITPA hydrolyses XTP to XMP - Rattus norvegicus [Reaction:R-RNO-2509838] ITPA hydrolyses dITP to dIMP - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-74259] Purine catabolism - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Purine catabolism
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-74259
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8956319] Nucleotide catabolism
(inferredTo)	[Pathway:R-HSA-74259] Purine catabolism

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