Reactome | ITPA hydrolyses dITP to dIMP

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ITPA hydrolyses dITP to dIMP Show undefined attributes

catalystActivity	[CatalystActivity:10167233] dITP diphosphatase activity of ITPA dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10167235
displayName	ITPA hydrolyses dITP to dIMP
eventOf	[Pathway:R-RNO-74259] Purine catabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2509838] ITPA hydrolyses dITP to dIMP - Homo sapiens
input	[SimpleEntity:R-ALL-2509835] dITP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ITPA hydrolyses dITP to dIMP dITP + H2O => dIMP + diphosphate + H(+)
output	[SimpleEntity:R-ALL-9731659] dIMP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
regulatedBy	[Requirement:R-HSA-9034457] Requirement by 'Mg2+ [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2509838
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-74259] Purine catabolism
(inferredTo)	[Reaction:R-HSA-2509838] ITPA hydrolyses dITP to dIMP

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