Reactome | MLKL binds HSP90:CDC37

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10213321
displayName	MLKL binds HSP90:CDC37
eventOf	[Pathway:R-RNO-5675482] Regulation of necroptotic cell death - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9698844] MLKL binds HSP90:CDC37 - Homo sapiens
input	[Complex:R-RNO-1225828] CDC37 [cytosol] [Complex:R-RNO-1221657] HSP90 [cytosol] [EntityWithAccessionedSequence:R-RNO-5218901] Mlkl [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MLKL binds HSP90:CDC37 MLKL+ HSP90 homodimer + CDC37 homodimer => MLKL:HSP90:CDC37
output	[Complex:R-RNO-9698842] MLKL:HSP90:CDC37 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9698844
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-5675482] Regulation of necroptotic cell death
(inferredTo)	[Reaction:R-HSA-9698844] MLKL binds HSP90:CDC37

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