Reactome | PELI1 binds activated RIPK1:RIPK3

Schema > Reaction > Entries

PELI1 binds activated RIPK1:RIPK3 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10212946
displayName	PELI1 binds activated RIPK1:RIPK3
eventOf	[Pathway:R-RNO-5675482] Regulation of necroptotic cell death - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-9686920] PELI1 ubiquitinates RIPK3 at K363 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9686922] PELI1 binds activated RIPK1:RIPK3 - Homo sapiens
input	[Complex:R-RNO-5218870] p-S166-RIPK1:p-S199,227-RIPK3 [cytosol] [EntityWithAccessionedSequence:R-RNO-450696] PELI1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PELI1 binds activated RIPK1:RIPK3
output	[Complex:R-RNO-9686923] p-S-RIPK1:p-S199,227-RIPK3:PELI1 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9686922
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5675482] Regulation of necroptotic cell death
(precedingEvent)	[BlackBoxEvent:R-RNO-9686920] PELI1 ubiquitinates RIPK3 at K363
(inferredTo)	[Reaction:R-HSA-9686922] PELI1 binds activated RIPK1:RIPK3

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