Reactome | SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP

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SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP Show undefined attributes

catalystActivity	[CatalystActivity:10178005] ubiquitin-protein transferase activity of Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10178007
displayName	SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP
eventOf	[Pathway:R-RNO-5607761] Dectin-1 mediated noncanonical NF-kB signaling - Rattus norvegicus [Pathway:R-RNO-5676590] NIK-->noncanonical NF-kB signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-5607724] 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex - Rattus norvegicus
inferredFrom	[BlackBoxEvent:R-HSA-5607725] SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP - Homo sapiens
input	[Complex:R-RNO-5607693] Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] 4 × [DefinedSet:R-RNO-912722] K48-Ub [cytosol] [EntityWithAccessionedSequence:R-RNO-947632] UBA3 [cytosol] [EntityWithAccessionedSequence:R-RNO-4419894] Ube2m [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP
output	[Complex:R-RNO-5607681] Active NIK:p-S176,180-IKKA dimer [cytosol] [Complex:R-RNO-5607694] K48-polyUb-p-7S-p100:RELB [cytosol] [Complex:R-RNO-5607687] SCF-beta-TRCP [cytosol] [EntityWithAccessionedSequence:R-RNO-947632] UBA3 [cytosol] [EntityWithAccessionedSequence:R-RNO-4419894] Ube2m [cytosol]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5607725
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5676590] NIK-->noncanonical NF-kB signaling [Pathway:R-RNO-5607761] Dectin-1 mediated noncanonical NF-kB signaling
(precedingEvent)	[BlackBoxEvent:R-RNO-5607724] 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
(inferredTo)	[BlackBoxEvent:R-HSA-5607725] SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP

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