Reactome | Active NIK:p-S176,180-IKKA dimer [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-5607690] Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-5607720] p100:RELB binds active NIK:p-IKKA dimer - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10177957
displayName	Active NIK:p-S176,180-IKKA dimer [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-RNO-168189] Map3k14 [cytosol] [Complex:R-RNO-5607702] p-S176,S180-IKKA dimer [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-5607681] Active NIK:p-S176,180-IKKA dimer [cytosol] - Homo sapiens
maxDepth	3
name	Active NIK:p-S176,180-IKKA dimer
producedByEvent	[Reaction:R-RNO-5607722] Active NIK phosphorylates IKKA dimer - Rattus norvegicus [BlackBoxEvent:R-RNO-5607725] SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5607681
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-RNO-5607722] Active NIK phosphorylates IKKA dimer [BlackBoxEvent:R-RNO-5607725] SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP
(input)	[Reaction:R-RNO-5607720] p100:RELB binds active NIK:p-IKKA dimer
(hasComponent)	[Complex:R-RNO-5607690] Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] [Complex:R-RNO-5607698] Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol]
(inferredTo)	[Complex:R-HSA-5607681] Active NIK:p-S176,180-IKKA dimer [cytosol]