Reactome | NIK-->noncanonical NF-kB signaling

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NIK-->noncanonical NF-kB signaling Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224683
displayName	NIK-->noncanonical NF-kB signaling
eventOf	[Pathway:R-RNO-5668541] TNFR2 non-canonical NF-kB pathway - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2132767] non-canonical NF-kappaB signal transduction
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-5607721] Activation of NIK - Rattus norvegicus [Reaction:R-RNO-5668545] NIK autophosphorylates on T559 - Rattus norvegicus [Reaction:R-RNO-5607722] Active NIK phosphorylates IKKA dimer - Rattus norvegicus [Reaction:R-RNO-5607720] p100:RELB binds active NIK:p-IKKA dimer - Rattus norvegicus [Reaction:R-RNO-5607726] Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB - Rattus norvegicus [Reaction:R-RNO-5607723] SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB - Rattus norvegicus [BlackBoxEvent:R-RNO-5607725] SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP - Rattus norvegicus [BlackBoxEvent:R-RNO-5607731] 26S proteasome processes p-7S-p100:RELB to form p52:RELB - Rattus norvegicus [Reaction:R-RNO-5607741] p52:RELB translocates from cytosol to nucleus - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-5676590] NIK-->noncanonical NF-kB signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	NIK-->noncanonical NF-kB signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5676590
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5668541] TNFR2 non-canonical NF-kB pathway
(inferredTo)	[Pathway:R-HSA-5676590] NIK-->noncanonical NF-kB signaling