Reactome | SLC22A18 exchanges extracellular organic cations for cytosolic H+

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SLC22A18 exchanges extracellular organic cations for cytosolic H+ Show undefined attributes

catalystActivity	[CatalystActivity:10143541] xenobiotic transmembrane transporter activity of SLC22A18 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10143543
displayName	SLC22A18 exchanges extracellular organic cations for cytosolic H+
eventOf	[Pathway:R-RNO-549127] SLC-mediated transport of organic cations - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-597628] SLC22A18 exchanges extracellular organic cations for cytosolic H+ - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [DefinedSet:R-ALL-597604] SLC22A18 substrates [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC22A18 exchanges extracellular organic cations for cytosolic H+ ORCTL2 mediates the transport of chloroquine and quinidine with efflux of protons
output	[SimpleEntity:R-ALL-351626] H+ [extracellular region] [DefinedSet:R-ALL-597623] SLC22A18 substrates [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-597628
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-549127] SLC-mediated transport of organic cations
(inferredTo)	[Reaction:R-HSA-597628] SLC22A18 exchanges extracellular organic cations for cytosolic H+

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