Reactome | MATEs mediate extrusion of xenobiotics

Schema > Reaction > Entries

MATEs mediate extrusion of xenobiotics Show undefined attributes

catalystActivity	[CatalystActivity:10139717] transmembrane transporter activity of MATE1/2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10139719
displayName	MATEs mediate extrusion of xenobiotics
eventOf	[Pathway:R-RNO-549127] SLC-mediated transport of organic cations - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-434650] MATEs mediate extrusion of xenobiotics - Homo sapiens
input	[SimpleEntity:R-ALL-351626] H+ [extracellular region] [DefinedSet:R-ALL-446589] MATE substrates [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MATEs mediate extrusion of xenobiotics
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [DefinedSet:R-ALL-446597] MATE substrates [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-434650
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-549127] SLC-mediated transport of organic cations
(inferredTo)	[Reaction:R-HSA-434650] MATEs mediate extrusion of xenobiotics

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