Reactome | FEN1 [nucleoplasm]

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FEN1 [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:10103679] 5'-flap endonuclease activity of FEN1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-RNO-110407] APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-5651725] PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-5651812] APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-5649866] PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-110364] PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 - Rattus norvegicus [Reaction:R-RNO-5687484] PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site - Rattus norvegicus [Reaction:R-RNO-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10103678
displayName	FEN1 [nucleoplasm]
endCoordinate	380
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-54745] FEN1 [nucleoplasm] - Homo sapiens
maxDepth	1
name	FEN1 Q5XIP6
producedByEvent	[Reaction:R-RNO-5687664] FEN1 cleaves displaced ssDNA flaps during MMEJ - Rattus norvegicus
referenceEntity	[ReferenceGeneProduct:uniprot:Q5XIP6] UniProt:Q5XIP6
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48895] Rattus norvegicus
stId	R-RNO-54745
startCoordinate	1

Referrals

(input)	[Reaction:R-RNO-110364] PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 [Reaction:R-RNO-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site [Reaction:R-RNO-5687484] PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site
(hasComponent)	[Complex:R-RNO-5651812] APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] [Complex:R-RNO-110407] APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] [Complex:R-RNO-5649866] PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] [Complex:R-RNO-5649888] PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] [Complex:R-RNO-5651725] PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] [Complex:R-RNO-5651754] FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] [Complex:R-RNO-5687514] Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] [Complex:R-RNO-5687655] Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] [Complex:R-RNO-5687643] Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm]
(output)	[Reaction:R-RNO-5687664] FEN1 cleaves displaced ssDNA flaps during MMEJ
(activeUnit)	[CatalystActivity:10184504] 5'-flap endonuclease activity of Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm]
(physicalEntity)	[CatalystActivity:10103679] 5'-flap endonuclease activity of FEN1 [nucleoplasm]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-54745] FEN1 [nucleoplasm]

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