Reactome | PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site

Schema > Reaction > Entries

PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10180453
displayName	PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site
eventOf	[Pathway:R-RNO-110362] POLB-Dependent Long Patch Base Excision Repair - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5649883] POLB-mediated DNA strand displacement synthesis - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-54745] FEN1 [nucleoplasm] [Complex:R-RNO-5649884] PARP1,PARP2 dimers [nucleoplasm] [Complex:R-RNO-5649885] POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site
output	[EntityWithAccessionedSequence:R-RNO-50119] APEX1 [nucleoplasm] [Complex:R-RNO-5649866] PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm]
precedingEvent	[Reaction:R-RNO-111253] POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site - Rattus norvegicus
regulatedBy	[PositiveRegulation:10180454] Positive regulation by 'PARG [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5649873
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-110362] POLB-Dependent Long Patch Base Excision Repair
(precedingEvent)	[Reaction:R-RNO-5649883] POLB-mediated DNA strand displacement synthesis
(inferredTo)	[Reaction:R-HSA-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site

Cite Us!