Reactome | Regulation of FZD by ubiquitination

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Regulation of FZD by ubiquitination Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224607
displayName	Regulation of FZD by ubiquitination
eventOf	[Pathway:R-RNO-201681] TCF dependent signaling in response to WNT - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-4641253] ZNRF3 ubiquitinates FZD to promote its downregulation - Rattus norvegicus [Reaction:R-RNO-4641206] RSPOs bind LGRs - Rattus norvegicus [Reaction:R-RNO-4641205] RSPO:LGR binds ZNRF3 - Rattus norvegicus [Reaction:R-RNO-4641246] ZNRF3 autoubiquitinates to promote its internalization - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-4641263] Regulation of FZD by ubiquitination - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of FZD by ubiquitination
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-4641263
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-201681] TCF dependent signaling in response to WNT
(inferredTo)	[Pathway:R-HSA-4641263] Regulation of FZD by ubiquitination

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