Reactome | RSPO:LGR binds ZNRF3

Schema > Reaction > Entries

RSPO:LGR binds ZNRF3 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10173617
displayName	RSPO:LGR binds ZNRF3
eventOf	[Pathway:R-RNO-4641263] Regulation of FZD by ubiquitination - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-4641246] ZNRF3 autoubiquitinates to promote its internalization - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-4641205] RSPO:LGR binds ZNRF3 - Homo sapiens
input	[Complex:R-RNO-4641201] RSPO:LGR [plasma membrane] [DefinedSet:R-RNO-5323542] ZNRF3,RNF43 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	RSPO:LGR binds ZNRF3
output	[Complex:R-RNO-4641203] RSPO:LGR:ZNRF3,RNF43 [plasma membrane]
precedingEvent	[Reaction:R-RNO-4641206] RSPOs bind LGRs - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-4641205
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-4641263] Regulation of FZD by ubiquitination
(precedingEvent)	[Reaction:R-RNO-4641246] ZNRF3 autoubiquitinates to promote its internalization
(inferredTo)	[Reaction:R-HSA-4641205] RSPO:LGR binds ZNRF3