Reactome | RSPOs bind LGRs

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10173619
displayName	RSPOs bind LGRs
eventOf	[Pathway:R-RNO-4641263] Regulation of FZD by ubiquitination - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-4641205] RSPO:LGR binds ZNRF3 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-4641206] RSPOs bind LGRs - Homo sapiens
input	[DefinedSet:R-RNO-4641170] LGR [plasma membrane] [DefinedSet:R-RNO-4641198] RSPO [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	RSPOs bind LGRs
output	[Complex:R-RNO-4641201] RSPO:LGR [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-4641206
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-4641263] Regulation of FZD by ubiquitination
(precedingEvent)	[Reaction:R-RNO-4641205] RSPO:LGR binds ZNRF3
(inferredTo)	[Reaction:R-HSA-4641206] RSPOs bind LGRs