Reactome | RSPOs bind LGRs

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RSPOs bind LGRs Show undefined attributes

authored	[InstanceEdit:4610796] Rothfels, K, 2013-09-23
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:4641207] Rothfels, K, 2013-09-27
dbId	4641206
displayName	RSPOs bind LGRs
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-4641263] Regulation of FZD by ubiquitination - Homo sapiens
followingEvent	[Reaction:R-HSA-4641205] RSPO:LGR binds ZNRF3 - Homo sapiens
input	[DefinedSet:R-HSA-4641170] LGR [plasma membrane] [DefinedSet:R-HSA-4641198] RSPO [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4641102] ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner [LiteratureReference:4641113] LGR4 and LGR5 are R-spondin receptors mediating Wnt/?-catenin and Wnt/PCP signalling [LiteratureReference:4641124] Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling [LiteratureReference:4641098] R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling [LiteratureReference:4641118] R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6 [LiteratureReference:4641104] R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling [LiteratureReference:4641097] Mitogenic influence of human R-spondin1 on the intestinal epithelium [LiteratureReference:4641099] R-Spondin proteins: a novel link to beta-catenin activation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	RSPOs bind LGRs
orthologousEvent	[Reaction:R-GGA-4641206] RSPOs bind LGRs - Gallus gallus [Reaction:R-XTR-4641206] RSPOs bind LGRs - Xenopus tropicalis [Reaction:R-DRE-4641206] RSPOs bind LGRs - Danio rerio [Reaction:R-SSC-4641206] RSPOs bind LGRs - Sus scrofa [Reaction:R-BTA-4641206] RSPOs bind LGRs - Bos taurus [Reaction:R-CFA-4641206] RSPOs bind LGRs - Canis familiaris [Reaction:R-RNO-4641206] RSPOs bind LGRs - Rattus norvegicus [Reaction:R-MMU-4641206] RSPOs bind LGRs - Mus musculus
output	[Complex:R-HSA-4641201] RSPO:LGR [plasma membrane]
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4641206
summation	[Summation:4641204] There are four human RSpondin genes in humans whose products...

Referrals

(precedingEvent)	[Reaction:R-HSA-4641205] RSPO:LGR binds ZNRF3
(hasEvent)	[Pathway:R-HSA-4641263] Regulation of FZD by ubiquitination

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