Reactome | Syk activation leads to SLP-76 activation

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Syk activation leads to SLP-76 activation Show undefined attributes

catalystActivity	[CatalystActivity:10138824] protein tyrosine kinase activity of p-Y348-SYK [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10138826
displayName	Syk activation leads to SLP-76 activation
eventOf	[Pathway:R-RNO-114604] GPVI-mediated activation cascade - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-430158] p-SLP-76 binds VAV - Rattus norvegicus [Reaction:R-RNO-430190] p-SLP-76 binds NCK - Rattus norvegicus [BlackBoxEvent:R-RNO-429497] SLP-76 stimulates PLC gamma 2 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-429449] Syk activation leads to SLP-76 activation - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-RNO-202306] Lcp2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Syk activation leads to SLP-76 activation
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-RNO-202175] phospho-Lcp2 [cytosol]
precedingEvent	[Reaction:R-RNO-453183] p-Y348-SYK dissociates - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-429449
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-114604] GPVI-mediated activation cascade
(precedingEvent)	[Reaction:R-RNO-430158] p-SLP-76 binds VAV [Reaction:R-RNO-430190] p-SLP-76 binds NCK [BlackBoxEvent:R-RNO-429497] SLP-76 stimulates PLC gamma 2
(inferredTo)	[Reaction:R-HSA-429449] Syk activation leads to SLP-76 activation

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