Reactome | APC promotes disassembly of beta-catenin transactivation complex

Schema > BlackBoxEvent > Entries

APC promotes disassembly of beta-catenin transactivation complex Show undefined attributes

category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10170858
displayName	APC promotes disassembly of beta-catenin transactivation complex
eventOf	[Pathway:R-RNO-3769402] Deactivation of the beta-catenin transactivating complex - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-3361751] beta-catenin is replaced by repression complexes at the promoter - Rattus norvegicus
inferredFrom	[BlackBoxEvent:R-HSA-3364042] APC promotes disassembly of beta-catenin transactivation complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-3361755] Apc [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-3361753] Btrc [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-212372] CTBP1 [nucleoplasm] [Complex:R-RNO-3361369] TCF/LEF:CTNNB1:BCL9:PYGO:MLL2:MEN1 complex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	APC promotes disassembly of beta-catenin transactivation complex
output	[DefinedSet:R-RNO-3305844] BCL9 [nucleoplasm] [Complex:R-RNO-9818683] MLL2 complex:MEN1 [nucleoplasm] [DefinedSet:R-RNO-3322379] PYGO [nucleoplasm] [Complex:R-RNO-3361754] TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm]
precedingEvent	[Reaction:R-RNO-3364014] Recruitment of MLL2 methyltransferase complex - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-3364042
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-3769402] Deactivation of the beta-catenin transactivating complex
(precedingEvent)	[BlackBoxEvent:R-RNO-3361751] beta-catenin is replaced by repression complexes at the promoter
(inferredTo)	[BlackBoxEvent:R-HSA-3364042] APC promotes disassembly of beta-catenin transactivation complex

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