Reactome | SLC6A12 (BGT-1)-mediated uptake of GABA and betaine

Schema > Reaction > Entries

SLC6A12 (BGT-1)-mediated uptake of GABA and betaine Show undefined attributes

catalystActivity	[CatalystActivity:10129839] amino acid transmembrane transporter activity of SLC6A12 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10129841
displayName	SLC6A12 (BGT-1)-mediated uptake of GABA and betaine
eventOf	[Pathway:R-RNO-888593] Reuptake of GABA - Rattus norvegicus [Pathway:R-RNO-352230] Amino acid transport across the plasma membrane - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-888592] Loading of GABA into clathrin sculpted GABA transport vesicle lumen - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-352029] SLC6A12 (BGT-1)-mediated uptake of GABA and betaine - Homo sapiens
input	2 × [SimpleEntity:R-ALL-188972] Cl- [extracellular region] [DefinedSet:R-ALL-352007] ligands of SLC6A12 (BGT-1) [extracellular region] 3 × [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC6A12 (BGT-1)-mediated uptake of GABA and betaine
output	2 × [SimpleEntity:R-ALL-352022] Cl- [cytosol] [DefinedSet:R-ALL-351982] ligands of SLC6A12 (BGT-1) [cytosol] 3 × [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-352029
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-352230] Amino acid transport across the plasma membrane [Pathway:R-RNO-888593] Reuptake of GABA
(precedingEvent)	[Reaction:R-RNO-888592] Loading of GABA into clathrin sculpted GABA transport vesicle lumen
(inferredTo)	[Reaction:R-HSA-352029] SLC6A12 (BGT-1)-mediated uptake of GABA and betaine

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