Reactome | Loading of GABA into clathrin sculpted GABA transport vesicle lumen

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Loading of GABA into clathrin sculpted GABA transport vesicle lumen Show undefined attributes

catalystActivity	[CatalystActivity:10144555] amino acid transmembrane transporter activity of SLC32A1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:917775] clathrin-sculpted gamma-aminobutyric acid transport vesicle lumen
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10144557
displayName	Loading of GABA into clathrin sculpted GABA transport vesicle lumen
eventOf	[Pathway:R-RNO-888590] GABA synthesis, release, reuptake and degradation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-917744] GABA loaded synaptic vesicle Docking and Priming - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-888592] Loading of GABA into clathrin sculpted GABA transport vesicle lumen - Homo sapiens
input	[SimpleEntity:R-ALL-352011] GABA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Loading of GABA into clathrin sculpted GABA transport vesicle lumen
output	[SimpleEntity:R-ALL-428571] GABA [clathrin-sculpted gamma-aminobutyric acid transport vesicle lumen]
precedingEvent	[Reaction:R-RNO-888577] Synthesis of GABA by GAD2 - Rattus norvegicus [Reaction:R-RNO-444007] GAT1-3 mediate Na+/Cl- dependent GABA transport - Rattus norvegicus [Reaction:R-RNO-352029] SLC6A12 (BGT-1)-mediated uptake of GABA and betaine - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-888592
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-888590] GABA synthesis, release, reuptake and degradation
(precedingEvent)	[Reaction:R-RNO-917744] GABA loaded synaptic vesicle Docking and Priming
(inferredTo)	[Reaction:R-HSA-888592] Loading of GABA into clathrin sculpted GABA transport vesicle lumen

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